A 4'x4' area is a lot of space, concentrate on the brood comb by tying it into empty frames. Keep the honey comb and use the crush and strain method of harvest.
This is going to be an all day job.
You'll find that the further you get into the comb removal that the bees will have a tendency to ball up in one area of the wall. If the queen isn't captured, this is most likely where she'll be.
After all of the comb, brood and honey have been removed then gather this ball of bees just as if it were a new swarm. Once back at the beeyeard unite the bees and brood comb with the hive containing the ball of bees.
Put the ball on the bottom as it will have framed foundation which is what you want to transfer the hive onto. Then as the foundation is drawn out the bees will move onto it. As the brood from the tied in frames hatch remove those frames and replace with either drawn comb or foundation.