>I know that some of the literature says get rid of her at least a couple of hours before requeening or combining but several of the oldtimers around here have say to wait as much as 2 days.
Jay Smith, who probably reared more queens than anyone who ever lived, said it takes two hours. I like overnight (like bout 8 to 12 hours) the best. But no more than 24 hours.
> Can waiting too (after disposing of the deficient queen) long create issues that wouldn't develope otherwise?
Yes If you wait more than 24 hours they will start queen cells if they can and that can interfere with acceptance of your queen.
Two days is a bad idea, unless you go in and remove all the queen cells. Overnight is much simpler as you don't have to worry about missing a queen cell.