My own worry is guarding such a large space from preditors, hive beetles, wax moth, ants and mice and anything that can make home in the super - this takes all the energy away from normal hive duties and your bees lose all productivity and protection.
The "75%-80% full super BEFORE adding another one" rule of adding a super gives you a large enough count of bees to both run all the normal hive duties AND also put enough workers in the added super to drawl out comb, transfer honey, chase away invaders, etc.. The see available space AS the previous space is running out and they will go to work building it up - if you just stick a super above one that is barely drawn, the upper super will never be built up - it is a negative and un-natural enviroment for the bees and they avoid building it. It causes them to walk too much, with no real PLAN to tackle such a project.
JUST AS.... You are always best to have an entrance reducer that reflects the activity of the hive - in other words, an opening large enough for your bees to fly in and out unrestricted YET protect from invading swarms looking to take over the hive, or any insects or animals that can fit in a larger space.. gives your bees a feeling of READIED RESPONCE. Having too big an opening makes the uncomfortable because they cannot protect the entire space as well, so they are not relaxed nor working at their best.
The ONLY good reason to have a FULL HIVE ENTRANCE (rather than a restricted one) is ventilation - a line of workers fanning greatly to get air into the hive. If you have a hive 4 or 5 supers high, then a fully open entrance allows faster entrance and exiting without worrying about invaders.
You really set yourself up for wax moth if you just place empty or especially drawn frames to hives which haven't even gotten 50% of the lower frames drawn and being used. You need lots of bees to protect a hive and you never want too much space and too few bees to protect it. It just asks for trouble.
If nothing else, it causes your workers to get confused and ut their work efforts in a box that is a long time from being filled. Bees work closely together, they enjoy touching each other and passing the pheromone of the queen to each other. They do not enjoy huge spaces where they can just fumble around doing nothing. When you only live 5 to 6 weeks, you can't waste any time in a super that will not be draen on UNTIL the lower one is 80% full - it does not help or motivate them to harvest quicker, it confuses them and makes them nervous and in a higher alert mode, which GREATLY reduces productivity.
Hope that helps.