What do you mean by full size hive? Do you plan on removing the honey supers prior to moving them? That is what I do. If it is real hot, if you have to stop, try to park in the shade. The hive will be full and they will not bee able to get out of to reduce how much heat is generated from the bees. After you set them in their new location, let them settle for about 30 minutes. Although i have released them on numerous occasion right after getting them in place, with no problems, if they were handled roughly, they may take it out on you. They are usually just in a hurry to get out. Bee sure to have a full bee suit in the truck, for each person in the truck, just in case something happens and you have to put a bunch of angry bees back in their hives. If the local fire department gets called to the site, they will foam them down and kill all of them. Good luck.