I find the two most important issues are WIND and HUMIDITY. Tackle these and you should have no problem.
YES that is the most important and difficult. With my 43 years experience those 2 cause still troubles for me. One point is hive's sensitiveness for nosema.
I tryed with wire mesh bottom but on my windy place it caused 50% increase in food consumtion. One died and 2 was nearby , and 6 was in my experience. What a loss!
When we have snow plenty and hives are covered with snow nosema kills a lot of bees from hive. When snow is 30 cm and entrence is free to open air there is very few bees died on the bottom.
But I do not try to be 100% good beekeeper. I keep 20% extra hives and I sleep calmly all our long winter. Most troubles become when queens have got nosema, not one but 2-3 of my 15 hives.
Also I will get trouples if all my hives are healty at spring. So I have too much hives and lack of boxes and too much honey to sell.