First, make 100 percent sure you are queenless. If you are queenless, then need to determine if you need to save the hive or not. You can add a frame of brood (young brood, look for eggs) to save the hive. If the hive is really hurting, newspaper combine. If they are drone layers, shake the bees out and put the hive up for next spring. You just have to judge what you have and what you can do.