i am not familiar with that program, but lots of programs do not load on vista without an update. a couple of things to try. 1st, go to the web site for that program and see if there is any vista support. there may be an update, patch, or work-around. 2nd, if 1 does not help do not auto run the disk. open it and see if you have an administrator option, or if you can install the program manually from the disk.