I'd move any drone comb in the middle of the brood nest to the outside of the brood nest once they are drawn.
The reason for this should be obvious. The outside frames are always storage combs regardless of the cell size. Moving the larger cells to the outside of the box makes the bees use those as storage combs and allows the beekeeper to replace them with frames that can be drawn out with worker brood sized combs.
Drone combs are usually the outer combs within the brood nest so the brood boxes are configured thusly in a strong hive:
S S/D D/W W W W W W/D D/S S where S = storage comb, D = Drone comb, and W = Worker comb. The / means the comb is mixed with each side being used as denoted.
As you can see, if you want the bees to draw Worker comb you need to place the frames (foundation) in the 4 & 7 slots.
Of course bees will be bees and they can do some crazy things but as a general rule the brood box lay out is as illustrated.