Since no one replied, I will. I have had between 15 and 20 hives for about 10 years. I used Apistan until 5 years ago and then started using Sucrocide by spraying between the frames several times a year. Now I only use Sucrocide if I am combining, etc. I have very few mites (I test via sugar shake method). My unscientific opinion is that Sucrocide helped my bees to learn to groom the mites off of each other. And if you just open the hive and spray lightly between the frames, it's very easy to do.