Are you meaning upside down as in taking a frame with drawn comb and turning it upside down?
I understand that when comb is drawn it has a slight angle going up. As I have no experince in this and haven't observed a queen laying eggs, I am only guessing. I would think if she had any other choice she would lay in other areas before going to the upside down stuff. Now if she had no choice at all, and could not abscound..... That's a good question. Know anyone claiming that they have actually witnessed this?
If not perhaps I will try to find a way to give it a try.
I saw an article about a rotating hive.... now where was that? Can't remember anything being said about the ability of the queen.
Accusing me of being an expert?