I agree with MB.
From the look at the pattern, it looks well infected. If one found a few cells, I think culling the frame, and perhaps a 2 cycle treatment would be a possibility. But as it looks, I think I would shake the bees, burn the comb, and scorch the boxes.
You could do your own "holts milk test" to confirm AFB. But you probably already know down deep that this is AFB, from what you said about the neighbors hives.