The local state inspector has told us that we have Apistan resistant bees in our area so we our now using Checkmite instead.
That seems to be everywhere. It was reported in Italy Apistan resistancy, and a couple of years after that in Finland, and so on. It took to me 2 years to realize that the volume of mites near desaster was due to resistancy.
To handle acids seems at first guite difficult, but in reality it is really easy. People talk too much about difficulty of mites. I have had them 20 years and they are nearly friends.

They killed furious native bees to extinction. Well done.
I also use drone-off-method. I give 2 deep fames in the center of brood area and put in langstroth farrar foundation. So about 1/3- 1/4 of frame is for drone combs and I cut them off and give pupas and larvas for birds. Birs pick pupas at the same day I put them in buches.